Oral bisphosphonates

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Oral bisphosphonates and colorectal cancer

Use of oral bisphosphonates has been associated with a decreased risk of colorectal cancer (CRC), but the association may be related to residual confounding by healthy lifestyle or body mass index (BMI). Therefore, we conducted a prospective nested case-control study within the Kaiser Permanente, Northern California health system cohort. In total, 12,505 CRC cases were individually matched to 5...

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Oral Bisphosphonates and Risk of Cancer

Bisphosphonates are currently widely used in the treatment and prevention of osteoporosis, as well as in patients with cancer metastases to bone or multiple myeloma. With a 75 million people affected by osteoporosis in the US, Europe and Japan, this represents a significant population being treated with these medications [1]. The benefits conferred by bisphosphonates in terms of reduced mortali...

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Oral bisphosphonates for paediatric osteogenesis imperfecta?

www.thelancet.com Published online August 6, 2013 http://dx.doi.org/10.1016/S0140-6736(13)61531-7 1 Children and adolescents with osteogenesis imperfecta have numerous fractures, often after what would otherwise seem trivial trauma. Even in mild disease, the risk of breaking a long bone (femur, tibia, fi bula, humerus, radius, or ulna) is about 100 times higher than in the general population. A...

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Oral bisphosphonates-associated osteonecrosis in rheumatoid arthritis.

Adverse effects associated with the use of bisphosphonates are infrequent and consist of pyrexia, renal function impairment, and hypocalcemia. Bisphosphonates-associated osteonecrosis of the jaws is an uncommon but potentially serious complication of intravenous bisphosphonate therapy in cancer patients. The degree of risk for osteonecrosis in patients taking oral bisphosphonates, such as alend...

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Bisphosphonates and oral pathology I. General and preventive aspects.

Bisphosphonates constitute a group of drugs capable of modulating bone turnover, and reduce its remodelling when an excessive resorption occurs. This is why they are indicated in a large group of bone diseases like postmenopausal osteoporosis or osteolysis associated with breast cancer or multiple myeloma. Over the last years and due to their extensive use, many cases of complications associate...

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ژورنال

عنوان ژورنال: Cancer

سال: 2000

ISSN: 0008-543X,1097-0142

DOI: 10.1002/(sici)1097-0142(20000101)88:1<6::aid-cncr3>3.3.co;2-4